Molecular Approaches to Improving General Anesthetics
نویسندگان
چکیده
منابع مشابه
General anesthetics and molecular mechanisms of unconsciousness.
The term ‘‘anesthesia’’ was originally used by the ancient Greek surgeon Dioscorides and resurrected by Dr Oliver Wendell Holmes to describe the insensible state produced by inhalation of ether. The goals of general anesthesia include amnesia, unconsciousness (also termed hypnosis), and immobilization. By definition, general anesthetics reversibly produce all 3 of these therapeutic effects. Gen...
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Current concepts of the molecular and cellular mechanisms that underlie general anesthetic actions are incomplete. This is both surprising, given that leading scientists have approached this problem for more than a century, and unfortunate since this lack of knowledge limits our ability to employ these important drugs with optimal safety and efficacy. Considerable evidence now implicates agent-...
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PURPOSE OF REVIEW To summarize recent in-vitro and in-vivo research on molecular mechanisms of general anesthetics' actions. RECENT FINDINGS Classes of general anesthetics with distinct clinical profiles appear to induce amnesia, hypnosis, and immobility via different molecular targets. Propofol, etomidate, and barbiturates produce profound amnesia and hypnosis, but weak immobility, by enhanc...
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Onion bulb composition varies widely, both within and between varieties. Development of Allium gene sequence and mapping resources has enabled dissection of bulb composition traits through genetic analysis and physiological studies. The collaborative use of complementary genetic stocks has proved critical to this progress. Mutation scanning of the 5’ regions of genes has proved the most robust ...
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The study of genome rearrangement sites using full genome sequences is an important approach to revealing the nature of cancer and finding effective ways for cancer treatment. The progress in DNA sequencing could make the procedure of whole genome reading close to routine procedure of lower cost. The personal analysis of rearranged ends (PARE) method used for rearrangement study is reviewed. PA...
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ژورنال
عنوان ژورنال: Anesthesiology Clinics
سال: 2010
ISSN: 1932-2275
DOI: 10.1016/j.anclin.2010.08.004